Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors

@article{Walther2012NovelCP,
  title={Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors},
  author={W. Walther and Stefan Petkov and Olga N. Kuvardina and Jutta Aumann and Dennis Kobelt and Iduna Fichtner and Magdalena Lemm and J{\"o}rg Piontek and Ingolf E Blasig and Ulrike Stein and Peter M. Schlag},
  journal={Gene Therapy},
  year={2012},
  volume={19},
  pages={494-503}
}
Bacterial toxins are known to be effective for cancer therapy. Clostridium perfringens enterotoxin (CPE) is produced by the bacterial Clostridium type A strain. The transmembrane proteins claudin-3 and -4, often overexpressed in numerous human epithelial tumors (for example, colon, breast, pancreas, prostate and ovarian), are the targeted receptors for CPE. CPE binding to them triggers formation of membrane pore complexes leading to rapid cell death. In this study, we aimed at selective tumor… CONTINUE READING
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