Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study.

@article{Elens2011NovelCI,
  title={Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study.},
  author={Laure L Elens and Matthijs L. Becker and Vincent Haufroid and Albert Hofman and Loes E. Visser and Andr{\'e} G. Uitterlinden and Bruno C. Stricker and Ron H. N. van Schaik},
  journal={Pharmacogenetics and genomics},
  year={2011},
  volume={21 12},
  pages={861-6}
}
OBJECTIVES CYP3A4 is involved in the oxidative metabolism of many drugs and xenobiotics including the HMG-CoA reductase inhibitor simvastatin. The objective of this study was to investigate whether a new CYP3A4 functional single nucleotide polymorphism (SNP) in intron 6 (CYP3A4*22) modifies the effect of simvastatin on total cholesterol (TOTc) or LDL cholesterol (LDLc) reduction in a population-based cohort study. METHODS In a total of 80 incident simvastatin users, the association between… CONTINUE READING
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