Novel CCL21-Vault Nanocapsule Intratumoral Delivery Inhibits Lung Cancer Growth

@inproceedings{Kar2011NovelCN,
  title={Novel CCL21-Vault Nanocapsule Intratumoral Delivery Inhibits Lung Cancer Growth},
  author={Upendra K. Kar and Minu K. Srivastava and {\AA}sa Andersson and Felicita E Baratelli and Min Huang and Valerie A. Kickhoefer and Steven Dubinett and Leonard H Rome and Sherven P Sharma},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Based on our preclinical findings, we are assessing the efficacy of intratumoral injection of dendritic cells (DC) transduced with an adenoviral vector expressing the secondary lymphoid chemokine (CCL21) gene (Ad-CCL21-DC) in a phase I trial in advanced non-small cell lung cancer (NSCLC). While this approach shows immune enhancement, the preparation of autologous DC for CCL21 genetic modification is cumbersome, expensive and time consuming. We are evaluating a non-DC based approach… CONTINUE READING
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