Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase

@inproceedings{Brecher2015NovelBS,
  title={Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase},
  author={Matthew Brecher and Hui Chen and Binbin Liu and Nilesh K. Banavali and Susan A. Jones and Jing Zhang and Zhongqiao Li and Laura D Kramer and Hongmin Li and Volker Thiel},
  booktitle={PloS one},
  year={2015}
}
The flavivirus methyltransferase (MTase) is an essential enzyme that sequentially methylates the N7 and 2'-O positions of the viral RNA cap, using S-adenosyl-L-methionine (SAM) as a methyl donor. We report here that small molecule compounds, which putatively bind to the SAM-binding site of flavivirus MTase and inhibit its function, were identified by using virtual screening. In vitro methylation experiments demonstrated significant MTase inhibition by 13 of these compounds, with the most potent… CONTINUE READING
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