Novel Biocompatible Cationic Copolymers Based on Polyaspartylhydrazide Being Potent as Gene Vector on Tumor Cells

@article{Ogris2007NovelBC,
  title={Novel Biocompatible Cationic Copolymers Based on Polyaspartylhydrazide Being Potent as Gene Vector on Tumor Cells},
  author={Manfred Ogris and Arun Kumar Kotha and Nicole Tietze and Ernst Wagner and Fabio Salvatore Palumbo and Gaetano Giammona and Gennara Cavallaro},
  journal={Pharmaceutical Research},
  year={2007},
  volume={24},
  pages={2213-2222}
}
IntroductionThe reaction between α,β-poly(aspartylhydrazide) (PAHy), a water soluble synthetic polymer and 3-(carboxypropyl)trimethyl-ammonium chloride (CPTACl) produced copolymers bearing permanent positive charges (PAHy–CPTA) with molecular weight of 10 kDa and PAHy–CPTA copolymers differing in positive charge amount (18–58%) were chosen for biological investigations. Materials and methodsBiophysical properties of DNA/PAHy–CPTA polyplexes were evaluated in terms of DNA condensation, zeta… 
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    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
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