Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents.

@article{Zhang2007NovelBI,
  title={Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents.},
  author={Zhichao Zhang and Liji Jin and Xuhong Qian and Meijiao Wei and Yuanyuan Wang and Jing Wang and Yuanyuan Yang and Qin Xu and Yongting Xu and Fengyu Liu},
  journal={Chembiochem : a European journal of chemical biology},
  year={2007},
  volume={8 1},
  pages={113-21}
}
Apoptosis as a novel target for cancer chemotherapy has generated an intense demand for new apoptosis-inducing agents. The newly revealed role of protein families involved in the apoptosis pathway, and resistance to cytotoxic therapies have opened new avenues for the development of novel anticancer strategies. We have established a novel strategy to rapidly obtain protein-targeted, instead of conventional DNA-targeted, apoptosis inducers as antitumor leads. First, a novel organic non-DNA… CONTINUE READING
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