Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene

@article{Davies1999NovelBD,
  title={Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene},
  author={Joan M. Davies and Nicola Hawe and Jedrzej Kabarowski and Q Huang and Jingde Zhu and Normen Brand and Dominique Leprince and Philippe Dhordain and Martyn Cook and Gillian M. Morriss-Kay and Arthur Zelent},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={365-375}
}
BTB/POZ-domain C2H2 zinc(Zn)-finger proteins are encoded by a subfamily of genes related to the Drosophila gap gene krüppel. To date, two such proteins, PLZF and LAZ-3/BCL-6, have been implicated in oncogenesis. We have now identified a new member of this gene subfamily which encodes a 62 kDa Zn-finger protein, termed LRF, with a BTB/POZ domain highly similar to that of PLZF. Both human and mouse LRF genes, which localized to syntenic chromosomal regions (19p13.3 and 10B5.3, respectively), were… CONTINUE READING