Novel Approach to Meta-Analysis of Microarray Datasets Reveals Muscle Remodeling-related Drug Targets and Biomarkers in Duchenne Muscular Dystrophy

@inproceedings{Kotelnikova2012NovelAT,
  title={Novel Approach to Meta-Analysis of Microarray Datasets Reveals Muscle Remodeling-related Drug Targets and Biomarkers in Duchenne Muscular Dystrophy},
  author={Ekaterina Kotelnikova and Maria A. Shkrob and Mikhail A. Pyatnitskiy and Alessandra Ferlini and Nikolai Daraselia},
  booktitle={PLoS Computational Biology},
  year={2012}
}
Elucidation of new biomarkers and potential drug targets from high-throughput profiling data is a challenging task due to a limited number of available biological samples and questionable reproducibility of differential changes in cross-dataset comparisons. In this paper we propose a novel computational approach for drug and biomarkers discovery using comprehensive analysis of multiple expression profiling datasets.The new method relies on aggregation of individual profiling experiments… CONTINUE READING
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