Novel Adiponectin Variants Identified in Type 2 Diabetic Patients Reveal Multimerization and Secretion Defects

@inproceedings{Jungtrakoon2011NovelAV,
  title={Novel Adiponectin Variants Identified in Type 2 Diabetic Patients Reveal Multimerization and Secretion Defects},
  author={Prapaporn Jungtrakoon and Nattachet Plengvidhya and Watip Tangjittipokin and Sarin Chimnaronk and Wanisa Salaemae and Nalinee Chongjaroen and Kanjana Chanprasert and Jatuporn Sujjitjoon and Chatchawan Srisawat and Pa-Thai Yenchitsomanus},
  booktitle={PloS one},
  year={2011}
}
ADIPOQ, encoding adiponectin, is a candidate gene for type 2 diabetes (T2D) identified by genome-wide linkage analyses with supporting evidence showing the protein function in sensitizing insulin actions. In an endeavor to characterize candidate genes causing T2D in Thai patients, we identified 10 novel ADIPOQ variations, several of which were non-synonymous variations observed only in the patients. To examine the impact of these non-synonymous variations on adiponectin structure and… CONTINUE READING
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