Novel Activation of STAT 5 b in Response to Epidermal Growth Factor *

@inproceedings{Kloth2002NovelAO,
  title={Novel Activation of STAT 5 b in Response to Epidermal Growth Factor *},
  author={Michael T. Kloth and Andrew D. Catling and Corinne M. Silva},
  year={2002}
}
  • Michael T. Kloth, Andrew D. Catling, Corinne M. Silva
  • Published 2002
Of the seven signal transducers and activators of transcription that have been identified, STATs 1, 3, and 5a/5b can be activated not only by a multitude of cytokines but also by some growth factors. The data presented here demonstrate that, in contrast to activation by the cytokine, growth hormone (GH), the activation of STAT5b by the growth factor, epidermal growth factor (EGF), requires overexpression of the EGF receptor (EGFR). We have shown that EGF activates STAT5b not only in a HEK293… CONTINUE READING