Novel ATP-competitive kinesin spindle protein inhibitors.

@article{Parrish2007NovelAK,
  title={Novel ATP-competitive kinesin spindle protein inhibitors.},
  author={Cynthia A Parrish and Nicholas D. Adams and Kurt R. Auger and Joelle L Burgess and Jeffrey D Carson and Amita M Chaudhari and Robert A Copeland and Melody A Diamond and Carla A Donatelli and Kevin J Duffy and Leo F Faucette and Jeffrey T. Finer and William F Huffman and Erin D Hugger and Jeffrey R. Jackson and Steven D. Knight and Lusong Luo and Michael Lane Moore and Ken A Newlander and Lance H Ridgers and Roman Sakowicz and Antony N Shaw and C M Sung and David E. Sutton and K. Wood and Shu-Yun Zhang and Michael N Zimmerman and Dashyant Dhanak},
  journal={Journal of medicinal chemistry},
  year={2007},
  volume={50 20},
  pages={4939-52}
}
Kinesin spindle protein (KSP), an ATPase responsible for spindle pole separation during mitosis that is present only in proliferating cells, has become a novel and attractive anticancer target with potential for reduced side effects compared to currently available therapies. We report herein the discovery of the first known ATP-competitive inhibitors of KSP, which display a unique activity profile as compared to the known loop 5 (L5) allosteric KSP inhibitors that are currently under clinical… CONTINUE READING

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