Novel 4,5-dihydro-thiazinogeldanamycin in a gdmP mutant strain of Streptomyces hygroscopicus 17997.

@article{Lin2011Novel4I,
  title={Novel 4,5-dihydro-thiazinogeldanamycin in a gdmP mutant strain of Streptomyces hygroscopicus 17997.},
  author={Ling Lin and Siyang Ni and Linzhuan Wu and Yiguang Wang and Yucheng Wang and Peizhen Tao and Weiqing He and Xiangjing Wang},
  journal={Bioscience, biotechnology, and biochemistry},
  year={2011},
  volume={75 10},
  pages={2042-5}
}
Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic… CONTINUE READING

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