Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents.

@article{Tanaka2009Novel3,
  title={Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents.},
  author={Reiko Tanaka and Hiroko Tsujii and Takeshi Yamada and Tetsuya Kajimoto and Fumio Amano and Junya Hasegawa and Yoshio Hamashima and Manabu Node and Kayoko Katoh and Y. Takebe},
  journal={Bioorganic & medicinal chemistry},
  year={2009},
  volume={17 14},
  pages={5238-46}
}
Sixteen novel compounds; 3alpha-methoxyserrat-14-en-21beta-ol (1) and 3beta-methoxyserrat-14-en-21beta-ol (2) and their curcumin, kojic acid, quercetin, and baicalein conjugates (3)-(18) were designed, synthesized, and evaluated for in vitro anti-HIV-1 reverse transcriptase (RT) activity in infected C8166-CCR5 cells, a human CD4(+) T-lymphocyte cell line. Among them, kojic acid derivatives, 9-12 showed significant biological activity. In particular, the compound 13, the conjugate of two… CONTINUE READING