Novel 3-phenylcoumarin-lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease.

@article{Jalilibaleh2018Novel3A,
  title={Novel 3-phenylcoumarin-lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease.},
  author={Leili Jalili-baleh and Hamid Nadri and Hamid Forootanfar and Alireza Samzadeh-kermani and Tuba T{\"u}yl{\"u} K{\"u}ç{\"u}kkılınç and Beyza Ayazgok and Mahban Rahimifard and Maryam Baeeri and Mohsen Doostmohammadi and Loghman Firoozpour and Syed Nasir Abbas Bukhari and Mohammad Abdollahi and Mohammad Reza Ganjali and Saeed Emami and Mehdi Khoobi and Alireza Foroumadi},
  journal={Bioorganic chemistry},
  year={2018},
  volume={79},
  pages={
          223-234
        }
}
  • Leili Jalili-baleh, Hamid Nadri, +13 authors Alireza Foroumadi
  • Published in Bioorganic chemistry 2018
  • Medicine, Chemistry
  • New series of triazole-containing 3-phenylcoumarin-lipoic acid conjugates were designed as multi-functional agents for treatment of Alzheimer's disease. The target compounds 4a-o were synthesized via the azide-alkyne cycloaddition reaction and their biological activities were primarily evaluated in terms of neuroprotection against H2O2-induced cell death in PC12 cells and AChE/BuChE inhibition. The promising compounds 4j and 4i containing four carbons spacer were selected for further biological… CONTINUE READING

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