Novel 2-pyrazoline derivatives as potential anticonvulsant agents

  title={Novel 2-pyrazoline derivatives as potential anticonvulsant agents},
  author={Shradha Bhandari and Avinash Chandra Tripathi and Shailendra K Saraf},
  journal={Medicinal Chemistry Research},
A series of new 2-pyrazoline derivatives has been synthesized by reacting 3-(substituted-phenyl)-1-pyridin-2-yl-propenones using two routes one using thiosemicarbazide and the other by hydrazine hydrate. The chemical structures were established by IR, Mass, 1H-NMR, 13C-NMR spectroscopic data, and elemental analysis. The anticonvulsant activity of the synthesized compounds was evaluated by the “maximal electroshock seizure” (MES) test and pentylenetetrazole (PTZ) test using male albino mice… CONTINUE READING
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Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 34 references

Harrison’s principles of internal medicine, vol Volume-II, 16th edn

  • DH Lowenstein, DL Kasper, E Braunwald, SL Hauser, DL Longo, JL Jameson
  • Mc Graw-Hill Medical Publishing Division,
  • 2005
Highly Influential
2 Excerpts

Design , synthesis , preliminary pharmacological evaluation and docking studies of pyrazoline derivatives

  • N Das, B Dash, M Dhanawat, SK Shrivastava
  • Chem Pap
  • 2012
1 Excerpt

3 D QSAR : exploring influence of parameters of pyrazoline analogues on resistant strains of staphylococcus aureus

  • MS Bhatia, KB Ingale, PB Choudhari, BE Zarekar, NM Bhatia, AS Sherikar
  • Int J Drug Des Discov
  • 2010
1 Excerpt

Synthesis and biological evaluation of some novel 1,3,5trisubstituted pyrazolines

  • BC Revanasiddappa, RN Rao, EVS Subrahmanyam, D Satyanarayana
  • E J Chem
  • 2010
2 Excerpts

Synthesis and inhibitory

  • A Granese, M Yanez, F Orallo
  • 2010

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