Novel 2-pyrazoline derivatives as potential anticonvulsant agents

@article{Bhandari2013Novel2D,
  title={Novel 2-pyrazoline derivatives as potential anticonvulsant agents},
  author={Shradha Bhandari and Avinash Chandra Tripathi and Shailendra K Saraf},
  journal={Medicinal Chemistry Research},
  year={2013},
  volume={22},
  pages={5290-5296}
}
A series of new 2-pyrazoline derivatives has been synthesized by reacting 3-(substituted-phenyl)-1-pyridin-2-yl-propenones using two routes one using thiosemicarbazide and the other by hydrazine hydrate. The chemical structures were established by IR, Mass, 1H-NMR, 13C-NMR spectroscopic data, and elemental analysis. The anticonvulsant activity of the synthesized compounds was evaluated by the “maximal electroshock seizure” (MES) test and pentylenetetrazole (PTZ) test using male albino mice… CONTINUE READING
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