Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA.

@article{Vourloumis2002Novel2D,
  title={Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA.},
  author={Dionisios Vourloumis and Masayuki Takahashi and Geoffrey C Winters and Klaus B{\ae}k Simonsen and Benjamin K Ayida and Sofia Barluenga and Seema S Qamar and Sarah Shandrick and Qiang Zhao and Thomas Hermann},
  journal={Bioorganic & medicinal chemistry letters},
  year={2002},
  volume={12 23},
  pages={3367-72}
}
The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is replaced by heterocycles.