Novel 1-oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines: synthesis, selectively analgesic action, and QSAR analysis.

Abstract

Based on the knowledge that imidazoline can result in analgesic action due to its selective binding with the prostacyclin receptor, 20 1-oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines (3a-t) were prepared in moderate yields. At 0.13 mmol/kg dose, their in vivo analgesic activities were evaluated after the mice were administered at 30, 60, 90, and… (More)

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Cite this paper

@article{Zhao2007Novel1S, title={Novel 1-oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines: synthesis, selectively analgesic action, and QSAR analysis.}, author={Ming Zhao and Zheng Li and Li Peng and Yu-Rong Tang and Chao Wang and Ziding Zhang and Shiqi Peng}, journal={Bioorganic & medicinal chemistry}, year={2007}, volume={15 8}, pages={2815-26} }