Novel “Superspreader” Bacteriophages Promote Horizontal Gene Transfer by Transformation

  title={Novel “Superspreader” Bacteriophages Promote Horizontal Gene Transfer by Transformation},
  author={Eric C. Keen and Valery V. Bliskovsky and Francisco Malag{\'o}n and James D. Baker and Jeffrey Scott Prince and James S. Klaus and Sankar Adhya},
Bacteriophages infect an estimated 1023 to 1025 bacterial cells each second, many of which carry physiologically relevant plasmids (e.g., those encoding antibiotic resistance). However, even though phage-plasmid interactions occur on a massive scale and have potentially significant evolutionary, ecological, and biomedical implications, plasmid fate upon phage infection and lysis has not been investigated to date. Here we show that a subset of the natural lytic phage population, which we dub… CONTINUE READING
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