Novel ω-Conotoxins from Conus catus Discriminate among Neuronal Calcium Channel Subtypes*

@article{Lewis2000NovelF,
  title={Novel $\omega$-Conotoxins from Conus catus Discriminate among Neuronal Calcium Channel Subtypes*},
  author={R J Lewis and Katherine J. Nielsen and David J. Craik and Marion L. Loughnan and Denise A. Adams and Iain A. Sharpe and Tudor Luchian and David John Adams and Trudy Bond and Linda Thomas and A E Jones and J Matheson and Roger Drinkwater and Peter R. Andrews and Paul F. Alewood},
  journal={The Journal of Biological Chemistry},
  year={2000},
  volume={275},
  pages={35335 - 35344}
}
ω-Conotoxins selective for N-type calcium channels are useful in the management of severe pain. In an attempt to expand the therapeutic potential of this class, four new ω-conotoxins (CVIA–D) have been discovered in the venom of the piscivorous cone snail, Conus catus, using assay-guided fractionation and gene cloning. Compared with other ω-conotoxins, CVID has a novel loop 4 sequence and the highest selectivity for N-type over P/Q-type calcium channels in radioligand binding assays. CVIA−D… 

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TLDR
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TLDR
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ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels
TLDR
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TLDR
The synthetic SO-3 has high analgesic activity similar to ω-conotoxin MVIIA (MVIIA), a selective N-type CaV channel blocker approved in the USA and Europe for the alleviation of persistent pain states, and in electrophysiological studies,SO-3 shows more selectivity towards the N- type CaV channels than M VIIA.
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