Corpus ID: 42957616

Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.

@article{Obukowicz1998NovelSD,
  title={Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.},
  author={Mark Gerard Obukowicz and Dean J. Welsch and William J. Salsgiver and Cynthia L. Martin-Berger and Kevin S Chinn and Kevin L. Duffin and Amiram Raz and Philip Needleman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={287 1},
  pages={
          157-66
        }
}
Decreased synthesis of arachidonic acid by inhibition of the Delta6 or Delta5 desaturase was evaluated as a means to mitigate inflammation. Using quantitative in vitro and in vivo radioassays, novel compounds representing five classes of Delta5 desaturase inhibitors and one class of Delta6 desaturase inhibitor were identified. The Delta6 desaturase inhibitor, SC-26196, had pharmacokinetic and pharmacodynamic profiles in mice that allowed for the evaluation of the pharmacological effects of… Expand
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