Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice

@article{Obukowicz2007NovelS,
  title={Novel, selective $\Delta$6 or $\Delta$5 fatty acid desaturase inhibitors as antiinflammatory agents in mice},
  author={M. Obukowicz and D. Welsch and W. Salsgiver and C. Martin-Berger and K. Chinn and K. Duffin and A. Raz and P. Needleman},
  journal={Lipids},
  year={2007},
  volume={34},
  pages={S149}
}
Decreased synthesis of arachidonic acid by inhibition of the Delta6 or Delta5 desaturase was evaluated as a means to mitigate inflammation. Using quantitative in vitro and in vivo radioassays, novel compounds representing five classes of Delta5 desaturase inhibitors and one class of Delta6 desaturase inhibitor were identified. The Delta6 desaturase inhibitor, SC-26196, had pharmacokinetic and pharmacodynamic profiles in mice that allowed for the evaluation of the pharmacological effects of… Expand
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