Novel, negatively charged, human serum albumins display potent and selective in vitro anti-human immunodeficiency virus type 1 activity.

@article{Jansen1993NovelNC,
  title={Novel, negatively charged, human serum albumins display potent and selective in vitro anti-human immunodeficiency virus type 1 activity.},
  author={Robert W. Jansen and Dominique Schols and Rudi Pauwels and Erik de Clercq and Dirk K. F. Meijer},
  journal={Molecular pharmacology},
  year={1993},
  volume={44 5},
  pages={1003-7}
}
We prepared a series of modified proteins and peptides by derivatizing the positively charged epsilon-amino groups of the lysine amino acids through reaction with anhydrides of succinic acid (Suc) and aconitic acid (Aco). Human serum albumin (HSA) was modified by introduction of a single carboxylic group (Suc-HSA) or two carboxylic groups (Aco-HSA) per amine function, yielding strongly negatively charged compounds. The in vitro anti-human immunodeficiency virus (HIV)-1 IC50 of Suc-HSA was about… CONTINUE READING

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