Novel, highly specific N-demethylases enable bacteria to live on caffeine and related purine alkaloids.

@article{Summers2012NovelHS,
  title={Novel, highly specific N-demethylases enable bacteria to live on caffeine and related purine alkaloids.},
  author={Ryan Michael Summers and Tai Man Louie and Chi-Li Yu and Lokesh Gakhar and Kailin C. Louie and Mani Subramanian},
  journal={Journal of bacteriology},
  year={2012},
  volume={194 8},
  pages={2041-9}
}
The molecular basis for the ability of bacteria to live on caffeine as a sole carbon and nitrogen source is unknown. Pseudomonas putida CBB5, which grows on several purine alkaloids, metabolizes caffeine and related methylxanthines via sequential N-demethylation to xanthine. Metabolism of caffeine by CBB5 was previously attributed to one broad-specificity… CONTINUE READING