Novel, dynamic on-line analytical separation system for dissolution of drugs from poly(lactic acid) nanoparticles.

Abstract

A novel method for investigating drug release in a dynamic manner from nanoparticles including, but not limited to, biodegradable poly(lactic acid) (PLA) is reported. The PLA nanoparticles were prepared by the nanoprecipitation method. Two poorly soluble drugs, beclomethasone dipropionate (BDP) and indomethacin, were encapsulated into PLA nanoparticles, and… (More)
DOI: 10.1016/j.jpba.2009.08.021

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