Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development

@article{Ubah2017NovelAV,
  title={Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development},
  author={Obinna C. Ubah and J. Steven and M. Kovaleva and L. Ferguson and Charlotte Barelle and A. Porter and C. Barelle},
  journal={Frontiers in Immunology},
  year={2017},
  volume={8}
}
  • Obinna C. Ubah, J. Steven, +4 authors C. Barelle
  • Published 2017
  • Medicine
  • Frontiers in Immunology
  • The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics. Despite this undoubted treatment success, a combination of acquired resistance together with an increased risk of systemic complications, means that a significant number of patients either fail to find a suitable targeted therapy or frustratingly discover that an approach… CONTINUE READING
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