Novaeguinoside II inhibits cell proliferation and induces apoptosis of human brain glioblastoma U87MG cells through the mitochondrial pathway

@article{Zhou2011NovaeguinosideII,
  title={Novaeguinoside II inhibits cell proliferation and induces apoptosis of human brain glioblastoma U87MG cells through the mitochondrial pathway},
  author={Jie Zhou and Gang Cheng and Guang Cheng and Hai-Feng Tang and Xiaomei Zhang},
  journal={Brain Research},
  year={2011},
  volume={1372},
  pages={22-28}
}
Saponin B, a novel cytostatic compound purified from Anemone taipaiensis, induces apoptosis in a human glioblastoma cell line.
TLDR
The novel compound, saponin B, effectively induces the apoptosis of GBM cells and inhibits glioma cell growth and survival and may be a potential candidate for the development of novel cancer therapeutics with antitumor activity against gliomas.
Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells.
TLDR
Investigation of the potential anti-proliferative and pro-apoptotic activity of asterosaponin 1 in A549 human lung cancer cells showed that it inhibited the proliferation of A549 cells in a dose-dependent manner, and the cytostatic activity resulted from the induction of apoptotic cell death.
Saponin 6 derived from Anemone taipaiensis induces U87 human malignant glioblastoma cell apoptosis via regulation of Fas and Bcl‑2 family proteins.
TLDR
The current study indicated that saponin 6 may exhibit selective cytotoxicity toward U87 MG cells by activating apoptosis via the extrinsic and intrinsic pathways, and may possess therapeutic potential for the treatment of GBM.
Embelin-induced brain glioma cell apoptosis and cell cycle arrest via the mitochondrial pathway.
TLDR
Investigating the role that the mitochondrial pathway plays in embelin-induced brain glioma cell apoptosis and the effect of embelin on the cell cycle found that embelin induced a time‑ and dose‑dependent apoptosis of brainglioma cells, and that it could arrest thecell cycle in the G0/G1 phase.
Inhibition of δ-opioid receptors induces brain glioma cell apoptosis through the mitochondrial and protein kinase C pathways
TLDR
The inhibition of δ-opioid receptors may inhibit brain glioma cell proliferation and lead to apoptosis, which is closely associated with the mitochondrial and PKC pathways.
CN-3 increases TMZ sensitivity and induces ROS-dependent apoptosis and autophagy in TMZ-resistance glioblastoma.
  • Yuehua Xue, Yun-Yang Lu, +5 authors Guang Cheng
  • Medicine
    Journal of biochemical and molecular toxicology
  • 2021
TLDR
CN-3 induced apoptosis and autophagy through ROS-mediated cytochrome C, cleaved-caspase 3, Bcl-2, P-AKT, PARP-1, and LC3-Ⅱ and had a synergistic cytotoxic effect with TMZ.
Effects of Polar Steroids from the Starfish Patiria (=Asterina) pectinifera in Combination with X-Ray Radiation on Colony Formation and Apoptosis Induction of Human Colorectal Carcinoma Cells
TLDR
Polar steroids from starfish Patiria (=Asterina) pectinifera enhanced the efficacy of radiation and, as a result, reduced the number and size of the colonies of colorectal cancer cells.
The Inhibitory Activity of Luzonicosides from the Starfish Echinaster luzonicus against Human Melanoma Cells
TLDR
Overall, the findings support a potential anti-cancer efficacy of luzonicosides A and D on human melanoma cells.
In Vitro Anticancer and Proapoptotic Activities of Steroidal Glycosides from the Starfish Anthenea aspera
TLDR
All investigated compounds (1–10) at nontoxic concentrations inhibited colony formation of human melanoma RPMI-7951, breast cancer T-47D, and colorectal carcinoma HT-29 cells to a variable degree.
Asterosaponins from the tropical starfish Acanthaster planci and their cytotoxic and anticancer activities in vitro
Abstract New asterosaponin, acanthaglycoside G (1), along with three previously known steroidal oligoglycosides (2‒4), were isolated from the ethanolic extract of the starfish Acanthaster planci,
...
1
2
...

References

SHOWING 1-10 OF 12 REFERENCES
Asterosaponin 1, a cytostatic compound from the starfish Culcita novaeguineae, functions by inducing apoptosis in human glioblastoma U87MG cells
TLDR
The data demonstrate that asterosaponin 1 is fully equipped for an efficient apoptotic killing of glioblastoma cells and suggest that this mechanism may play a critical role in anti-tumor chemotherapy.
Mitochondrial Transmembrane Potential Changes Support the Concept of Mitochondrial Heterogeneity During Apoptosis
TLDR
The hypothesis that ATP needed for completion of the apoptotic cascade can be generated during apoptosis in a subset of respiring mitochondria and is not necessarily derived from anaerobic glycolysis is supported.
Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry.
TLDR
The HO342/7-AAD method may be particularly applicable to studies of programmed cell death in cells in which DNA fragmentation is difficult to detect by decreased DNA stainability.
Three new asterosaponins from the starfish Culcita novaeguineae and their bioactivity.
TLDR
Three new sulfated steroidal glycosides (asterosaponins) 1, 2 and 3 are isolated, as active compounds causing morphological abnormality of Pyricularia oryzae mycelia, by bioassay-guided fractionation of the active n-BuOH extract of the starfish Culcita novaeguineae.
Mitochondrial-dependent apoptosis in experimental rodent abdominal aortic aneurysms.
Chemosensitivity testing of human lung cancer cell lines using the MTT assay.
TLDR
This panel of lung cancer cells exhibited a drug sensitivity profile paralleling that observed in clinical practice, suggesting that this lung cancer cell line panel in combination with a relatively simple but reproducible chemosensitivity assay, such as the MTT assay, has potential for the testing of drug combinations and evaluating new anti-cancer agents in vitro.
Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process
TLDR
It is found that when caspase activity is inhibited, mitochondrial outer membrane permeabilization causes a rapid depolarization of mitochondrial transmembrane potential, which recovers to original levels over the next 30–60 min and is then maintained.
An integrated set of methods for routine flow cytometric DNA analysis.
...
1
2
...