Nova-1 mediates glucocorticoid-induced inhibition of pre-mRNA splicing of gonadotropin-releasing hormone transcripts.

@article{Park2009Nova1MG,
  title={Nova-1 mediates glucocorticoid-induced inhibition of pre-mRNA splicing of gonadotropin-releasing hormone transcripts.},
  author={Eonyoung Park and Mi Sun Lee and Sun Mi Baik and Eun Bee Cho and Gi Hoon Son and Jae Young Seong and Kun Ho Lee and Kyungjin Kim},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 19},
  pages={12792-800}
}
Glucocorticoid (GC) is known to affect the reproductive system by suppressing the gonadotropin-releasing hormone (GnRH) gene expression in the hypothalamus. However, the mechanism of this effect is poorly understood. We show here that the GC-induced reduction of GnRH mRNA is due to attenuation of a post-transcriptional process i.e. splicing of intron A… CONTINUE READING