Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system

@article{Buckanovich1993NovaTP,
  title={Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system},
  author={Ronald J. Buckanovich and Jerome B. Posner and Robert B. Darnell},
  journal={Neuron},
  year={1993},
  volume={11},
  pages={657-672}
}

The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies

It is shown that Nova- 1 is a neuron-specific RNA-binding protein with sequence and functional similarities to FMR-1, a target antigen in a human paraneoplastic motor disorder and suggesting such inhibition may cause the neurological disease.

The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia.

  • Y. YangG. YinR. Darnell
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
The results demonstrate that the immune response in POMA targets a family of highly related sequence-specific neuronal RNA-binding proteins, and the expression pattern of the Nova-2 protein is likely to underlie the development of cognitive deficits in some PomA patients.

Paraneoplastic Encephalomyelitis Antigens Bind to the AU-rich Elements of mRNA

It is reported here that the Hu antigens bind avidly to the AU-rich element resident in many mRNAs that regulate cell proliferation, which suggests that theHu antIGens promote neuronal differentiation by suppressing the neuroblast cell cycle.

The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo

Nova-1 functions as a sequence-specific nuclear RNA binding protein in vivo; disruption of the specific interaction between Nova-1 and GlyR alpha2 pre-mRNA may underlie the motor dysfunction seen in POMA.

A Post-Transcriptional Regulatory Mechanism Restricts Expression of the Paraneoplastic Cerebellar Degeneration Antigen cdr2 to Immune Privileged Tissues

It is found that the cdr2 gene, which encodes a cytoplasmic leucine zipper protein of unknown function, is expressed in PCD-associated tumors, whereas other cdr genes are not; thus, cdr1 encodes the PCD tumor antigen and is compatible with the autoimmune model of PCD pathogenesis.

A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing.

It is suggested that brPTB is a tissue-restricted RNA binding protein that interacts with and inhibits the ability of Nova to activate exon selection in neurons.

Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.

The mouse chromosomal locations of nine genes suggest that the Hua-Hud genes arose from gene duplication and dispersion, while the other genes are dispersed in the genome.

Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders.

It is demonstrated that some patients with paraneoplastic neurological disorders develop antibodies against Mal, a new member of an expanding family of 'brain/testis' proteins.
...

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