Notum deacylates Wnt proteins to suppress signalling activity.


Signalling by Wnt proteins is finely balanced to ensure normal development and tissue homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a highly conserved secreted feedback antagonist. Notum has been thought to act as a phospholipase, shedding glypicans and associated Wnt proteins from the cell surface. However, this… (More)
DOI: 10.1038/nature14259


Cite this paper

@article{Kakugawa2015NotumDW, title={Notum deacylates Wnt proteins to suppress signalling activity.}, author={Satoshi Kakugawa and Paul Francis Langton and Matthias Zebisch and Steve N. G. Howell and Tao-Hsin Chang and Yan Liu and Ten E N Feizi and Ganka Bineva and Nicola O'Reilly and Ambrosius P Snijders and E Yvonne Jones and Jean-Paul Vincent}, journal={Nature}, year={2015}, volume={519 7542}, pages={187-192} }