Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation.

@article{Zhang2015NotoginsenosideRA,
  title={Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation.},
  author={Jingjing Zhang and Lili Ding and Baocan Wang and Gaiyan Ren and Aning Sun and Chao Deng and Xiaohui Wei and Sridhar Mani and Zhengtao Wang and Wei Dou},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2015},
  volume={352 2},
  pages={315-24}
}
  • Jingjing Zhang, Lili Ding, +7 authors Wei Dou
  • Published 2015 in
    The Journal of pharmacology and experimental…
  • DOI:10.1124/jpet.114.218750
Notoginsenoside R1 (R1) is the main bioactive component in Panax notoginseng, an old herb medicine widely used in Asian countries in the treatment of microcirculatory diseases. However, little is known about the effect of R1 on inflammatory bowel disease (IBD). The present study demonstrated that R1 alleviated the severity of dextran sulfate sodium-induced colitis in mice by decreasing the activity of myeloperoxidase, the production of cytokines, the expression of proinflammatory genes, and the… CONTINUE READING
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