Noteworthy observations accompanying synthesis of the apoptolidin disaccharide.

Abstract

A stereoselective synthesis of the apoptolidin disaccharide is reported. The key chemistry features a new transformation utilizing a highly selective tetramethylalkoxyalanate[v]-directed syn-methylation of a vinylogous ester, isolation of a hydrate of a 2-keto sugar, an eco-friendly radical cleavage of a bromomethyl group, and an efficient preparation of a… (More)
DOI: 10.1039/c1cc11448d

Topics

Cite this paper

@article{Srinivasarao2011NoteworthyOA, title={Noteworthy observations accompanying synthesis of the apoptolidin disaccharide.}, author={Madduri Srinivasarao and Taesik Park and Yuzhong Chen and Philip L. Fuchs}, journal={Chemical communications}, year={2011}, volume={47 20}, pages={5858-60} }