Notch3 overexpression as potential therapeutic target in advanced stage chemoresistant ovarian cancer.

@article{Rahman2012Notch3OA,
  title={Notch3 overexpression as potential therapeutic target in advanced stage chemoresistant ovarian cancer.},
  author={Mohammed Tanjimur Rahman and Kentaro Nakayama and Munmun Rahman and Hiroshi Katagiri and Atsuko Katagiri and Tomoka Ishibashi and Masako Ishikawa and Kouji Iida and Satoru Nakayama and Yoshiro Otsuki and Kohji Miyazaki},
  journal={American journal of clinical pathology},
  year={2012},
  volume={138 4},
  pages={535-44}
}
This study examined the clinical significance of Notch3 expression and assessed its usefulness as a potential therapeutic target in chemoresistant ovarian cancer. Notch3 expression was assessed with immunohistochemical examination, and clinical variables were collected with a retrospective chart review. Notch3 siRNA or γ-secretase inhibitor was used to assess Notch3 function in ovarian cancer cell lines. Notch3 overexpression correlated with shorter progression-free/overall survival in patients… CONTINUE READING
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Ovarian cancer

  • KR Cho, M. Shih Ie
  • Annu Rev Pathol
  • 2009

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