Notch3 null mutation in mice causes muscle hyperplasia by repetitive muscle regeneration.

@article{Kitamoto2010Notch3NM,
  title={Notch3 null mutation in mice causes muscle hyperplasia by repetitive muscle regeneration.},
  author={Takeo Kitamoto and Kazunori Hanaoka},
  journal={Stem cells},
  year={2010},
  volume={28 12},
  pages={2205-16}
}
Satellite cells are skeletal muscle stem cells responsible for growth, maintenance, and repair of postnatal skeletal muscle. Although several studies have demonstrated that Notch signaling plays a critical role in muscle regeneration through promoting proliferation and self-renewal of satellite cells, the function of Notch3 is yet to be elucidated. We analyzed muscle regeneration in Notch3-deficient mutant mice. We found a remarkable overgrowth of muscle mass in the Notch3-deficient mice but… CONTINUE READING

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