Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles

@inproceedings{Xu2012Notch2IR,
  title={Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles},
  author={Jingxia Xu and Thomas Gridley},
  booktitle={BMC Biology},
  year={2012}
}
In the mouse ovary, oocytes initially develop in clusters termed germ-cell nests. Shortly after birth, these germ-cell nests break apart, and the oocytes individually become surrounded by somatic granulosa cells to form primordial follicles. Notch signaling plays essential roles during oogenesis in Drosophila, and recent studies have suggested that Notch signaling also plays an essential role during oogenesis and ovary development in mammals. However, no in vivo loss-of-function studies have… CONTINUE READING
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