Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells.

Abstract

Recent studies have implicated a role for Notch in the generation of marginal zone (MZ) B cells. To further investigate the role of Notch in the B cell lineage, we have analyzed the effects of reduced Notch2 signaling in mice expressing one functional allele of Notch2 (Notch2(+/-)). Notch2(+/-) mice have reduced B1 B cells of the peritoneal cavity and show… (More)

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@article{Witt2003Notch2HR, title={Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells.}, author={Colleen M. Witt and Woong-Jai Won and Vincent Hurez and Christopher A. Klug}, journal={Journal of immunology}, year={2003}, volume={171 6}, pages={2783-8} }