Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination.

@article{Zhang2009Notch1SP,
  title={Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination.},
  author={Yueting Zhang and Azeb Tadesse Argaw and Blake T. Gurfein and Andleeb Zameer and Brian Jeffrey Snyder and Changhui Ge and Qing Richard Lu and David H Rowitch and Cedric S Raine and Celia F. Brosnan and Gareth R. John},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 45},
  pages={19162-7}
}
In the developing CNS, Notch1 and its ligand, Jagged1, regulate oligodendrocyte differentiation and myelin formation, but their role in repair of demyelinating lesions in diseases such as multiple sclerosis remains unresolved. To address this question, we generated a mouse model in which we targeted Notch1 inactivation to oligodendrocyte progenitor cells (OPCs) using Olig1Cre and a floxed Notch1 allele, Notch1(12f). During CNS development, OPC differentiation was potentiated in Olig1Cre:Notch1… CONTINUE READING

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