Notch1 receptor as a marker of lymph node metastases in papillary thyroid cancer.

@article{Park2012Notch1RA,
  title={Notch1 receptor as a marker of lymph node metastases in papillary thyroid cancer.},
  author={Hyung Seok Park and C J Jung and Sung Hak Lee and Byung Joo Chae and Dong Jun Lim and Woo Chan Park and Byung Joo Song and Jeong Soo Kim and Sang Seol Jung and Ja Seong Bae},
  journal={Cancer science},
  year={2012},
  volume={103 2},
  pages={305-9}
}
Notch functions as an oncogene or tumor suppressor according to the type of malignancy, and the BRAF(V600E) mutation is commonly observed in thyroid cancer. However, the role of Notch and BRAF(V600E) in papillary thyroid cancer (PTC) is unclear. This study sought to elucidate the clinicopathological characteristics in patients with PTC regarding the expression of Notch1/Notch3 receptors and BRAF(V600E) mutation. Clinicopathological characteristics were evaluated according to the Notch1/Notch3… CONTINUE READING
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