Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.

@article{McGowan2011Notch1IA,
  title={Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.},
  author={Patricia M. McGowan and Carmen Simedrea and Emeline J. Ribot and Paula J. Gareau Foster and Diane C Palmieri and Patricia S. Steeg and Alison L Allan and Ann F. Chambers},
  journal={Molecular cancer research : MCR},
  year={2011},
  volume={9 7},
  pages={
          834-44
        }
}
Brain metastasis from breast cancer is an increasingly important clinical problem. Here we assessed the role of CD44(hi)/CD24(lo) cells and pathways that regulate them, in an experimental model of brain metastasis. Notch signaling (mediated by γ-secretase) has been shown to contribute to maintenance of the cancer stem cell (CSC) phenotype. Cells sorted for a reduced stem-like phenotype had a reduced ability to form brain metastases compared with unsorted or CD44(hi)/CD24(lo) cells (P < 0.05… CONTINUE READING
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