Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors

@article{Ling2010Notch1inducedMT,
  title={Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors},
  author={Hua Ling and J-R Sylvestre and Paul Jolicoeur},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={4543-4554}
}
Members of the Notch family are involved in the development of breast cancer in animal models and in humans. In young transgenic mice, expressing intracellular activated Notch1 (N1IC) in mammary cells, we found that CD24+ CD29high progenitor cells had enhanced survival, and were expanded through a cyclin D1-dependent pathway. This expansion positively correlated with the later cyclin D1-dependent formation of basal-like ductal tumors. This expanded population exhibited abnormal differentiation… CONTINUE READING

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