Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells.

@article{Santos2007Notch1EB,
  title={Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells.},
  author={Margarida Almeida Santos and Leonor Morais Sarmento and Manuel M Rebelo and Ana Agua Doce and Ivan P Maillard and Alexis Dumortier and H. Chaves Neves and Freddy Radtke and Warren S Pear and Leonor Parreira and Jocelyne Demengeot},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 39},
  pages={15454-9}
}
Notch signaling regulates B and T lymphocyte development and T cell effector class decision. In this work, we tested whether Notch activity affects mature B cell activation and differentiation to antibody-secreting cells (ASC). We show increased frequency of ASC in cultures of splenic B cells activated with LPS or anti-CD40 when provided exogenous Notch ligand Delta-like-1 (Dll1). Our results indicate that Notch-Dll1 interaction releases a default pathway that otherwise inhibits Ig secretion… CONTINUE READING

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