Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas.

@article{Spaulding2007Notch1CL,
  title={Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas.},
  author={Christina Spaulding and Erica J Reschly and Derek E. Zagort and Yumi Yashiro-Ohtani and Levi J. Beverly and Anthony J. Capobianco and Warren S Pear and Barbara L Kee},
  journal={Blood},
  year={2007},
  volume={110 7},
  pages={2650-8}
}
Oncogenic Notch1 mutations are found in most T-lineage acute lymphoblastic leukemias in humans and T-cell lymphomas in mice. However, the mechanism by which Notch1 promotes transformation or maintains malignant cell survival has not been determined fully. Here, we report that expression of the transcription factor lymphoid enhancer factor 1 (Lef1) is Notch dependent in murine T-cell lymphomas in vitro and in vivo, and that the intracellular domain of Notch1 (ICN1) is present at the Lef1… CONTINUE READING
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