Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.

@article{Jang2015Notch1AV,
  title={Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.},
  author={Il Ho Jang and Yi-fen Lu and Long Zhao and Pamela L Wenzel and Tsutomu Kume and Sumon M. Datta and Natasha Arora and Jordi Guiu and Mounia Lagha and Peter Geon Kim and Eun Kyoung Do and Jae Ho Kim and Thorsten M. Schlaeger and Leonard I. Zon and Anna Bigas and C Geoffrey Burns and George Q. Daley},
  journal={Blood},
  year={2015},
  volume={125 9},
  pages={1418-26}
}
Hematopoietic and vascular development share many common features, including cell surface markers and sites of origin. Recent lineage-tracing studies have established that definitive hematopoietic stem and progenitor cells arise from vascular endothelial-cadherin(+) hemogenic endothelial cells of the aorta-gonad-mesonephros region, but the genetic programs underlying the specification of hemogenic endothelial cells remain poorly defined. Here, we discovered that Notch induction enhances… CONTINUE READING