Notch1-Dll4 signaling and mechanical force regulate leader cell formation during collective cell migration

@inproceedings{Riahi2015Notch1Dll4SA,
  title={Notch1-Dll4 signaling and mechanical force regulate leader cell formation during collective cell migration},
  author={Reza Riahi and Jian Sun and Shue Wang and Min Long and Donna D Zhang and Pak Kin Wong},
  booktitle={Nature communications},
  year={2015}
}
At the onset of collective cell migration, a subset of cells within an initially homogenous population acquires a distinct 'leader' phenotype with characteristic morphology and motility. However, the factors driving the leader cell formation as well as the mechanisms regulating leader cell density during the migration process remain to be determined. Here we use single-cell gene expression analysis and computational modelling to show that the leader cell identity is dynamically regulated by… CONTINUE READING
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