Notch signalling regulates cytokine production by CD8+ and CD4+ T cells.

@article{Sauma2012NotchSR,
  title={Notch signalling regulates cytokine production by CD8+ and CD4+ T cells.},
  author={Daniela Sauma and Alberto Jes{\'u}s Guarnido Ram{\'i}rez and Kellean Alvarez and Mario Rosemblatt and Mar{\'i}a Rosa Bono},
  journal={Scandinavian journal of immunology},
  year={2012},
  volume={75 4},
  pages={389-400}
}
The Notch signalling pathway regulates several aspects of cellular differentiation such as T lineage commitment and effector functions on peripheral T cells; however, there is limited information regarding Notch receptor expression on different T cell subsets and the putative role of the different receptors on T cell effector function. Here, we studied the protein expression of Notch receptors on murine T cells in vitro and in vivo and analysed the role of the Notch pathway in cytokine… CONTINUE READING