Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing

@article{Thlu2002NotchSI,
  title={Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing},
  author={Jacques Th{\'e}lu and Patricia Rossio and Bertrand Favier},
  journal={BMC Dermatology},
  year={2002},
  volume={2},
  pages={7 - 7}
}
BACKGROUND Epidermal homeostasis involves the monitoring of continuous proliferative and differentiative processes as keratinocytes migrate from the basal layer to the skin surface. Recently, differentiation of epidermal stem cells was shown to be promoted by the Notch pathway. This pathway is characterised by cell-cell interactions between transmembrane proteins and was first implicated in lateral inhibition, patterning and cell binary choices during embryogenesis. METHODS By in situ… CONTINUE READING

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