Notch signalling in context

@article{Bray2016NotchSI,
  title={Notch signalling in context},
  author={Sarah J Bray},
  journal={Nature Reviews Molecular Cell Biology},
  year={2016},
  volume={17},
  pages={722-735}
}
The highly conserved Notch signalling pathway functions in many different developmental and homeostatic processes, which raises the question of how this pathway can achieve such diverse outcomes. With a direct route from the membrane to the nucleus, the Notch pathway has fewer opportunities for regulation than do many other signalling pathways, yet it generates exquisitely patterned structures, including sensory hair cells and branched arterial networks. More confusingly, its activity promotes… CONTINUE READING
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