Notch signalling during peripheral T-cell activation and differentiation

  title={Notch signalling during peripheral T-cell activation and differentiation},
  author={B. Osborne and L. Minter},
  journal={Nature Reviews Immunology},
  • B. Osborne, L. Minter
  • Published 2007
  • Biology, Medicine
  • Nature Reviews Immunology
  • For many years, researchers have focused on the contribution of Notch signalling to lymphoid development. Only recently have investigators begun to ask what role, if any, Notch has during the activation and differentiation of naive CD4+ T cells in the periphery. As interest in this issue grows, it is becoming increasingly clear that the main role of Notch signalling, to regulate cell-fate decisions, might also be influential in peripheral T cells. 
    225 Citations

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Notch signaling in differentiation and function of dendritic cells
    • 41
    Notch signaling in CD4 and CD8 T cell development.
    • 59
    Notch 1 signalling in human T-cell development and leukemia
    Notch signaling and its emerging role in autoimmunity
    • 6
    Notch and its ligands in alloimmunity and rejection
    • 3
    • Highly Influenced
    Notch signaling and development of the hematopoietic system.
    • 22
    Notch Regulates Cytolytic Effector Function in CD8+ T Cells1
    • 119
    • PDF
    The Notch Signaling Pathway Controls Short-Lived Effector CD8+ T Cell Differentiation but Is Dispensable for Memory Generation
    • 33
    • Highly Influenced
    • PDF
    Notch signaling in the hematopoietic system
    • 57


    Notch signaling is an important regulator of type 2 immunity
    • 280
    • PDF
    Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells.
    • 204
    • PDF
    Notch Signaling Augments T Cell Responsiveness by Enhancing CD25 Expression 1
    • 221
    • PDF
    Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.
    • 68
    • PDF
    Notch signalling: a simple pathway becomes complex
    • S. J. Bray
    • Biology, Medicine
    • Nature Reviews Molecular Cell Biology
    • 2006
    • 2,174
    • PDF