Notch signaling suppresses IgH gene expression in chicken B cells: implication in spatially restricted expression of Serrate2/Notch1 in the bursa of Fabricius.

@article{Morimura2001NotchSS,
  title={Notch signaling suppresses IgH gene expression in chicken B cells: implication in spatially restricted expression of Serrate2/Notch1 in the bursa of Fabricius.},
  author={Toshifumi Morimura and Seiji Miyatani and Daisuke Kitamura and Ryo Goitsuka},
  journal={Journal of immunology},
  year={2001},
  volume={166 5},
  pages={3277-83}
}
The bursa of Fabricius is a central organ for chicken B cell development and provides an essential microenvironment for expansion of the B cell pool and for generation of a diversified B cell repertoire. We report here that genes encoding the Notch family of transmembrane proteins, key regulators of cell fate determination in development, are differentially expressed in the bursa of Fabricius: Notch1 is expressed in medullary B cells located close to the basement membrane-associated epithelium… CONTINUE READING
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