Notch signaling regulates growth and differentiation in the mammalian lens.

@article{Rowan2008NotchSR,
  title={Notch signaling regulates growth and differentiation in the mammalian lens.},
  author={Sheldon Rowan and Kevin W Conley and Tien T. Le and Amy L Donner and Richard L. Maas and Nadean L Brown},
  journal={Developmental biology},
  year={2008},
  volume={321 1},
  pages={111-22}
}
The Notch signal transduction pathway regulates the decision to proliferate versus differentiate. Although there are a myriad of mouse models for the Notch pathway, surprisingly little is known about how these genes regulate early eye development, particularly in the anterior lens. We employed both gain-of-function and loss-of-function approaches to determine the role of Notch signaling in lens development. Here we analyzed mice containing conditional deletion of the Notch effector Rbpj or… CONTINUE READING