Notch signaling regulates follicular helper T cell differentiation.

@article{Auderset2013NotchSR,
  title={Notch signaling regulates follicular helper T cell differentiation.},
  author={Floriane Auderset and Steffen Schuster and Nicolas Fasnacht and Manuel Coutaz and M{\'e}lanie Charmoy and Ute Koch and St{\'e}phanie Favre and Anne S Wilson and François Trottein and J. -P. Alexander and Sanjiv Luther and H Robson Macdonald and Freddy Radtke and Fabienne Tacchini-Cottier},
  journal={Journal of immunology},
  year={2013},
  volume={191 5},
  pages={2344-50}
}
Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but their control is not fully understood. In this study, we show that Notch signaling in T cells is a major player in the development and function of TFH cells. T cell-specific gene ablation of Notch1 and Notch2 impaired differentiation of TFH cells in draining lymph nodes of mice immunized with T… CONTINUE READING
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